From f6437500d6da09416e1a65b53bcdb00d11cf698e Mon Sep 17 00:00:00 2001 From: Alba Showalter Date: Sat, 16 Aug 2025 00:57:06 +0000 Subject: [PATCH] Add 'The Low Down on Male Muscle Exposed' --- The-Low-Down-on-Male-Muscle-Exposed.md | 1 + 1 file changed, 1 insertion(+) create mode 100644 The-Low-Down-on-Male-Muscle-Exposed.md diff --git a/The-Low-Down-on-Male-Muscle-Exposed.md b/The-Low-Down-on-Male-Muscle-Exposed.md new file mode 100644 index 0000000..1dcfb93 --- /dev/null +++ b/The-Low-Down-on-Male-Muscle-Exposed.md @@ -0,0 +1 @@ +
Prolonged residence of mice in spaceflight is a scientifically robust and ethically ratified model of muscle atrophy caused by continued unloading. Under the Rodent Research Program of the National Aeronautics and Space Administration (NASA), we assayed the large-scale mRNA and metabolomic perturbations in the quadriceps of C57BL/6j male mice that lived in spaceflight (FLT) or on the ground (control or CTR) for approximately 4 weeks. The wet weights of the quadriceps were significantly reduced in FLT mice. Next-generation sequencing and untargeted mass spectroscopic assays interrogated the gene-metabolite landscape of the quadriceps. A majority of top-ranked differentially suppressed genes in FLT encoded proteins from the myosin or troponin families, suggesting sarcomere alterations in space. Significantly enriched gene-metabolite networks were found linked to sarcomeric integrity, immune fitness, and oxidative stress response \ No newline at end of file